chromosomal instability การใช้

• It usually is a sign of genotoxic events and chromosomal instability.
• DCC would fall into the chromosomal instability category.
• This shows that chromosomal instability can be responsible for the development of solid cancers.
• SIRT2 has been proposed to act as a tumor suppressor by preventing chromosomal instability during mitosis.
• More generally, chromosomal instability is known to be induced by aromatic amines in urinary bladder cells.
• Both subunits of Ku have been experimentally chromosomal instability, indicating that NHEJ is important for genome maintenance.
• Powerful mutagens may result in chromosomal instability, causing chromosomal breakages and rearrangement of the chromosomes such as inversion.
• In humans, an MCM8 mutation can give rise to premature ovarian failure, as well as chromosomal instability.
• Most cells die quickly if a single alpha particle passes through them but survivors show " chromosomal instability ."
• Chromosomal instability resulting from dysfunctional caretaker genes is the most common form of genetic instability that leads to cancer in humans.
• The chromosomal instability resulting from this trinucleotide expansion presents clinically as intellectual disability, distinctive facial features, and macroorchidism in males.
• H2AX is an indicator of melanoma because of its high correlation to chromosomal instability ( Warters et al ., 2005 ).
• Most human cancers have been found to have gains and losses of chromosomes that may be due to chromosomal instability ( CIN ).
• Therefore, the relationship between chromosomal instability and cancer can also be used to assist with diagnosis of malignant vs . benign tumors.
• The reduced expressions of miR-223 may predispose to the development of hepatocellular carcinoma via the widespread induction of chromosomal instability by STMN1.
• Twenty six tests were carried out on mutant mice and one significant abnormality was observed : chromosomal instability was detect by a micronucleus test.
• A majority of human solid malignant tumors is characterized by chromosomal instability, and have gain or loss of whole chromosomes or fractions of chromosomes.
• These findings suggest that the microdeletion is a sign of a chromosomal instability that causes some cells to lose the entire Y chromosome, McElreavey says.
• High expression levels are usually seen before the tumor cells become immortalized and aneuploid which can contribute to the chromosomal instability and the aggressive nature of certain cancers.
• Ataxia with telangiectasia is a rare form ataxia that causes chromosomal instability, sensitivity to ionizing radiation, disrupted stress-activated signal transduction pathways and radioresistant DNA synthesis.